Use an Airport Expres Without iTunes (on a PC or Mac, Linux Too)

Like the idea of a remote speaker system – but don’t like being locked into iTunes? If you run a Mac or PC (Even Vista!) we recommend AirTunes. It is a standalone application that hooks into applications and transit their audio stream wirelessly.
If you are a Linux user, consider Raop_play. This application acts as a music file player for Apple Airport Express that can stream M3U files or act as a second sound card.
